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Skin Cancer

Basal Cell Carcinoma (BCC)

N.B. Most common type of skin cancer.


This is a locally-invasive, slow-growing tumour of epidermal keratinocytes.


Risk factors:

  • Fair skin

  • Hx of frequent/severe sun burns

  • Outdoor occupation or hobbies

  • Personal/family hx of skin cancer

  • Increasing age


Presentation:

  • Small, shiny, skin-coloured nodule with a central depression

  • Rolled edge

  • Telangiectasia

  • No pain or bleeding

  • Typically on sun-exposed areas


Management - Surgical excision

Basal cell carcinoma (https://commons.wikimedia.org/wiki/File:Basal_cell_carcinoma.jpg)

Squamous Cell Carcinoma (SCC)

This is a locally-invasive, malignant tumour of epidermal keratinocytes.


Risk factors:

  • Fair skin

  • Hx of frequent/severe sun burns

  • Outdoor occupation or hobbies

  • Personal/family hx of skin cancer

  • Increasing age


Presentation:

  • Irregular, ill-defined red nodule with scale and ulceration

  • Can be painful or bleeding

  • Typically on sun-exposed areas


Management - Surgical excision

Pathology: Patient: Squamous Cell Carcinoma Description: Tends to arise from pre-malignant lesions, actinic keratoses; surface is usually scaley and often ulcerate – James Heilman, MD (https://en.wikipedia.org/wiki/File:Squamous_Cell_Carcinoma1.jpg)

Melanoma

Presentation - ABCDE:

  • Asymmetry

  • Border irregularity

  • Colour variation

  • Diameter > 6mm

  • Evolves over time


Always suspect if a mole has any of the ABCDE characteristics. If present, the patient should be 2 week wait referred to a dermatologist.


The main prognostic tool is the Breslow thickness, which measures the depth of the cancer.


N.B. Most (70%) start off with superficial spreading before spreading vertically in the later stages.


Management - Surgical excision

 Part of the ABCDs for detection of melanoma. On the left side from top to bottom: melanomas showing (A) Asymmetry, (B) a border that is uneven, ragged, or notched, (C) coloring of different shades of brown, black, or tan and (D) diameter that had changed in size. The normal moles on the right side do not have abnormal characteristics (no asymmetry, even border, even color, no change in diametry). - National Cancer Institute via Skin Cancer Foundation (https://en.m.wikipedia.org/wiki/File:Melanoma_vs_normal_mole_ABCD_rule_NCI_Visuals_Online.jpg)

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